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Sarcoma and Bone Cancers

Sarcoma-bone Cancer






Soft Tissue and Bone sarcoma Hospital in Banjara Hills, Hyderabad

Sarcomas are rare cancers arising from bone, muscle, fat, blood vessels, or connective tissues. Because they are uncommon and often misdiagnosed as benign swellings, early specialist evaluation is critical. Our sarcoma care is centralized, protocol-driven, and tumor-board discussed. We focus on limb preservation, precision pathology, molecular profiling, and access to modern systemic therapies

What is Sarcoma?

Sarcomas are rare, complex cancers originating in the bones or soft tissues. Soft tissue sarcomas can arise in limbs, trunk or in abdomen commonly as retro peritoneal sarcomas.We provide protocol-driven care through a dedicated multidisciplinary team focused on precision and patient outcomes. Unlike common cancers, sarcomas require highly specialized knowledge for accurate diagnosis and effective limb-sparing treatments.

Bone Cancers

Osteosarcoma, Ewing Sarcoma, Chondrosarcoma.

Symptoms to Monitor
Persistent Bone Pain
Sometimes with fever
Swelling near joints
Unexplained fracture
Limping in children or adolescents
Diagnosis at HCC
MRI-based local staging
PET CT scan
CT chest for metastasis
Core needle biopsy (planned along surgical incision line)
Molecular testing (EWSR1 translocation in Ewing sarcoma)
Diagnosis at HCC
Neoadjuvant chemotherapy (standard osteosarcoma protocols)
Endoprosthetic reconstruction
Adjuvant chemotherapy
Radiation therapy (Ewing sarcoma)
Soft Tissue Sarcomas
Liposarcoma
Leiomyosarcoma
Synovial sarcoma
Undifferentiated pleomorphic sarcoma
GIST (managed under GI oncology protocol)

Treatment Approach at HCC

Surgical Oncology

Wide local excision with negative margins
Limb preservation wherever possible
Complex retroperitoneal resections

Radiation Therapy

Pre-operative radiation to shrink tumor
IMRT / image-guided radiation
Proton therapy referral where indicated

Systemic Therapy

Doxorubicin-based chemotherapy
Ifosfamide combinations
Eribulin (liposarcoma)
Pazopanib (advanced soft tissue sarcoma)

Precision & Immunotherapy

Pembrolizumab in selected subtypes
NTRK inhibitors in fusion-positive sarcomas
CDK4 amplification targeting in specific liposarcomas
MDM2 amplification testing

Pediatric & Young Adult Sarcomas

Sarcomas commonly affect children and adolescents. Treatment is protocol-driven and coordinated with pediatric oncology specialists. Fertility preservation counselling is offered before chemotherapy where appropriate.

Genetic & Hereditary Evaluation

Certain sarcomas are linked with inherited conditions: Li-Fraumeni syndrome (TP53 mutation), Neurofibromatosis type 1, Retinoblastoma mutation carriers. Genetic counselling and family screening are offered when indicated.

FAQ’s

Reviewed By

Medically Reviewed by : Dr. Srinivas Prasad, MCh (Surgical Oncology)
20+ years of experience in oncologic surgery and multidisciplinary cancer care.
Registration No: 2111
Last reviewed: February 2026

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