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Esophageal and Upper GI cancers

Esophageal Cancer






Best Gastrointestinal Cancer Hospital in Banjara Hills, Hyderabad

Esophageal, Gastric and Small Intestinal Cancers

Upper GI cancers affect the food pipe, stomach, and small intestine.These cancers often begin silently with mild acidity, difficulty swallowing, vague abdominal discomfort. At Horizon Cancer Centre (HCC), we approach upper GI cancers with precision diagnostics, molecular profiling, organ-preserving surgery, and advanced systemic therapies tailored to tumor biology.

Esophageal Cancer

Affects the food pipe, often identified by progressive difficulty swallowing, weight loss, and persistent reflux.

Types

Squamous cell
Adenocarcinoma

Genetic Evaluation

HER2, PD-L1, MSI

Treatment Approach

EMR, minimally invasive esophagectomy, neoadjuvant chemoradiation, immunotherapy (Nivolumab/Pembrolizumab).

Gastric Cancer

Common symptoms include early satiety, bloating, anemia, and unexplained weight loss.

Multidisciplinary Strategy

Staging laparoscopy, D2 lymph node dissection, FLOT protocols.

Hereditary Considerations

CDH1 mutation screening and counseling.

Targeted Therapy

Trastuzumab, Ramucirumab, Nivolumab/Pembrolizumab.

Small Intestinal Cancer

Less common but complex tumors requiring specialized surgical and systemic management.

Types

Adenocarcinoma
Neuroendocrine
GIST

Genetic Links

Lynch syndrome, FAP, Peutz-Jeghers.

Treatment Approach

Segmental resection, targeted therapy tailored to specific tumor markers.

Our Treatment Philosophy

Focus on the specific genetic and molecular blueprint of your cancer to ensure the highest chance of success.

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FAQ’s

  • Upper GI cancers include cancers of the esophagus (food pipe), stomach, and small intestine. These cancers affect the upper digestive tract and may cause symptoms related to swallowing, digestion, or unexplained weight loss.

When Should You Seek Evaluation?

Persistent difficulty or pain when swallowing
Unexplained and significant weight loss
Early satiety (feeling full after just a few bites)
Persistent bloating or gastrointestinal discomfort
New or worsening anemia (chronic fatigue)

Why Choose Horizon Cancer Centre?

Advanced molecular diagnostics
Access to immunotherapy & targeted drugs
Minimally invasive GI oncology surgery
Genetic counselling for hereditary cancers
Long-term follow-up care model

Reviewed By

Medically Reviewed by : Dr. Srinivas Prasad, MCh (Surgical Oncology)
20+ years of experience in oncologic surgery and multidisciplinary cancer care.
Registration No: 2111
Last reviewed: February 2026

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